MORCure Announces Research Project with Key Opinion Leader Prof. Yorgo Modis

Navigating a condition like MORC2-related disorder (CMT2Z / DIGFAN) is incredibly challenging due to the lack of information and the broad diversity of symptoms that makes each patient unique. When the literature is sparse, the community often becomes the expert voice to push the field forward.

To this end MORCure is absolutely delighted to be working in partnership with the University of Cambridge in our first ever dedicated research project on MORC2-related disorder led by leading scientist, Dr Yorgo Modis, Professor of Virology and Immunology and a Wellcome Trust Senior Research Fellow at the Department of Medicine, University of Cambridge. The project aims to generate new insights into how genetically inherited variants of the MORC2 gene cause disease, including severe neuropathies in young children. We are thrilled to have recruited Prof. Modis to apply his expertise and cutting-edge approaches to help us understand MORC2-Related disorder (M2RD). We firmly believe the work of Prof. Modis and his team will lead the way to identifying new ways to diagnose and treat this disorder.

Previous peer-reviewed studies published by Modis and colleagues have shown that MORC2 plays a vital role in regulating gene expression from the earliest stages of human embryonic development. In this new project, the Modis research group will apply a combination of state-of-the-art computational approaches, including AI-driven molecular modeling tools and molecular dynamics simulations, to obtain a detailed understanding of how specific genetically inherited mutations affect the function and regulation of the MORC2 protein.

“With an increasing number of families affected by M2RD, MORCure addresses an important need for a better understanding of the disorder, how to diagnose it and ultimately how to treat it”, said Prof. Modis. “We will draw on our deep expertise on MORC2 molecular structure and function to determine the effects of mutations associated with M2RD on the ability of MORC2 to perform its essential gene-regulatory functions. Integrating insights from powerful neural network-based computational models and molecular dynamics simulations on some of the fastest available processors will allow us to make accurate predictions of the individual effects of each known M2RD-associated mutation”.   

This project paves the way for experimental validation of our understanding of the molecular mechanism of transcriptional regulation by MORC2. MORCure and Prof. Modis plan to leverage these advances to enable the development of new diagnostics and medicines for M2RD patients.

As you are aware, MORCure works with a distinguished Medical Advisory Board and Board of Trustees to raise awareness of M2RD around the world, connecting patients and clinicians, and promoting research on a disorder that remains significantly underdiagnosed and misdiagnosed.

Thank you so much for being part of this journey to accelerate this essential research to enable us to change the lives of so many children and adults living extremely tough lives.

Anna-mai and the MORCure team.